Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P42336. Start with neoplasm, then reuse UniProt P42336 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P42336 as the stable protein anchor across project notes and exports.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ALPELISIB, BAY-1082439, COPANLISIB, COPANLISIB HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt P42336. Sequence length is 1068 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform as ChEMBL target CHEMBL4005, mapped to UniProt P42336. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform is the right protein anchor across sources, using UniProt P42336 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.
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| Preferred Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42336 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| UniProt Accession | P42336 |
| Component Type | Protein |
| Sequence Length | 1068 aa |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mapped to UniProt P42336. Sequence length is 1068 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ALPELISIB, BAY-1082439, COPANLISIB, COPANLISIB HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3770993 | 10.8 | Ki | 0.016 | Preclinical |
| CHEMBL1236962 | 10.72 | Ki | 0.019 | Clinical |
| CHEMBL1236962 | 10.72 | IC50 | 0.019 | Clinical |
| CHEMBL5953956 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL5778370 | 10.66 | Ki | 0.022 | Preclinical |
| CHEMBL6019298 | 10.64 | Ki | 0.023 | Preclinical |
| CHEMBL5750027 | 10.62 | Ki | 0.024 | Preclinical |
| CHEMBL5867381 | 10.62 | Ki | 0.024 | Preclinical |
| CHEMBL5208487 | 10.59 | Ki | 0.026 | Preclinical |
| CHEMBL5855663 | 10.59 | Ki | 0.026 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1,176 | 6,628 | 6.9 |
| assay format | 297 | 458 | 6.5 |
| cell-based format | 236 | 1,041 | 7.1 |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 36 | 6.4 |
| cell-based format | 3 | 11 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 6 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.8 |