Signal transducer and activator of transcription 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P40763. Use UniProt P40763 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P40763 as the stable identity anchor, then attach disease evidence before program review.
Signal transducer and activator of transcription 3
Review this target as Signal transducer and activator of transcription 3, mapped to UniProt P40763. Sequence length is 770 aa.
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This review treats Signal transducer and activator of transcription 3 as ChEMBL target CHEMBL4026, mapped to UniProt P40763. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Signal transducer and activator of transcription 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P40763 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Signal transducer and activator of transcription 3 |
| UniProt Accession | P40763 |
| Component Type | Protein |
| Sequence Length | 770 aa |
Signal transducer and activator of transcription 3
Review this target as Signal transducer and activator of transcription 3, mapped to UniProt P40763. Sequence length is 770 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1389016 | 8.98 | EC50 | 1.04 | Preclinical |
| CHEMBL1449962 | 8.66 | EC50 | 2.19 | Preclinical |
| CHEMBL5437070 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL1703740 | 8.34 | EC50 | 4.55 | Preclinical |
| CHEMBL3392776 | 8.33 | Kd | 4.7 | Clinical |
| CHEMBL4776801 | 8.29 | Ki | 5.1 | Preclinical |
| CHEMBL5177956 | 8.28 | IC50 | 5.3 | Preclinical |
| CHEMBL5439447 | 8.23 | IC50 | 5.9 | Preclinical |
| CHEMBL5209107 | 8.23 | IC50 | 5.9 | Preclinical |
| CHEMBL5405538 | 8.15 | IC50 | 7.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 895 | 547 | 5.7 |
| single protein format | 168 | 616 | 5.3 |
| subcellular format | 25 | 7 | 5.5 |
| tissue-based format | 25 | 3 | 4.8 |
| assay format | 17 | 32 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 6 | 0 | — |
| cell-based format | 5 | 89 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 17 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |