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Target Snapshot

CHEMBL4033 Target Snapshot

Cyclooxygenase-2 · SINGLE PROTEIN · Canis lupus familiaris

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133Compounds
7Assays
2Approved Drugs
136.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8SPQ9. Use UniProt Q8SPQ9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8SPQ9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cyclooxygenase-2 as ChEMBL target CHEMBL4033, mapped to UniProt Q8SPQ9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cyclooxygenase-2
SINGLE PROTEIN · Canis lupus familiaris
As of 2026-09-14
ChEMBL target ID
CHEMBL4033
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8SPQ9
Prostaglandin G/H synthase 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cyclooxygenase-2 is the right protein anchor across sources, using UniProt Q8SPQ9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCyclooxygenase-2
Target TypeSINGLE PROTEIN
OrganismCanis lupus familiaris
UniProtQ8SPQ9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProstaglandin G/H synthase 2
UniProt AccessionQ8SPQ9
Component TypeProtein
Sequence Length604 aa

Prostaglandin G/H synthase 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cyclooxygenase-2, mapped to UniProt Q8SPQ9. ChEMBL maps the protein component as Prostaglandin G/H synthase 2. Sequence length is 604 aa.

Mapped IDQ8SPQ9
Review nameCyclooxygenase-2
OrganismCanis lupus familiaris
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50136.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL378649 8.0 IC50 10.0 Preclinical
CHEMBL380148 8.0 IC50 10.0 Preclinical
CHEMBL383064 7.92 IC50 12.0 Preclinical
CHEMBL205351 7.89 IC50 13.0 Preclinical
CHEMBL380457 7.72 IC50 19.0 Preclinical
CHEMBL206359 7.7 IC50 20.0 Preclinical
CHEMBL370579 7.52 IC50 30.0 Preclinical
CHEMBL381834 7.52 IC50 30.0 Preclinical
CHEMBL204178 7.4 IC50 40.0 Preclinical
CHEMBL175485 7.36 IC50 44.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
5
5.5
14
6.0
54
6.5
23
7.0
6
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CELECOXIB
CHEMBL118
Approved 1998
Properties Compare Identifier
Assay Landscape

Assay Landscape

7
Total Assays
107
Tested Compounds
1
Assay Types
Binding — 7 assays, 107 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 89 6.6
tissue-based format 1 18 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine