Prolyl endopeptidase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt O70196. Use UniProt O70196 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O70196 as the stable identity anchor, then attach disease evidence before program review.
Prolyl endopeptidase
Review this target as Prolyl endopeptidase, mapped to UniProt O70196. Sequence length is 710 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prolyl endopeptidase as ChEMBL target CHEMBL4035, mapped to UniProt O70196. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Prolyl endopeptidase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O70196 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prolyl endopeptidase |
| UniProt Accession | O70196 |
| Component Type | Protein |
| Sequence Length | 710 aa |
Prolyl endopeptidase
Review this target as Prolyl endopeptidase, mapped to UniProt O70196. Sequence length is 710 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL189620 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL76578 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL458975 | 9.09 | IC50 | 0.81 | Preclinical |
| CHEMBL459149 | 9.06 | IC50 | 0.88 | Preclinical |
| CHEMBL305681 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL294803 | 9.02 | Ki | 0.95 | Preclinical |
| CHEMBL3236270 | 9.02 | Ki | 0.95 | Preclinical |
| CHEMBL80684 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL1087219 | 8.92 | IC50 | 1.2 | Preclinical |
| CHEMBL421519 | 8.92 | IC50 | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 58 | 8.0 |
| organism-based format | 6 | 0 | — |
| tissue-based format | 3 | 11 | 8.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 9 | 0 | — |