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Target Snapshot

CHEMBL4046 Target Snapshot

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 · SINGLE PROTEIN · Homo sapiens

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10Compounds
5Assays
0Approved Drugs
12.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q14643. Use UniProt Q14643 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q14643 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 as ChEMBL target CHEMBL4046, mapped to UniProt Q14643. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4046
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q14643
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 is the right protein anchor across sources, using UniProt Q14643 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ14643
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
UniProt AccessionQ14643
Component TypeProtein
Sequence Length2758 aa

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, mapped to UniProt Q14643. Sequence length is 2758 aa.

Mapped IDQ14643
Review nameInositol 1,4,5-trisphosphate-gated calcium channel ITPR1
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC501.0
KD11.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL172534 8.93 Kd 1.17 Preclinical
CHEMBL434103 6.85 Kd 140.0 Preclinical
CHEMBL169923 6.8 Kd 160.0 Preclinical
CHEMBL352326 6.77 Kd 170.0 Preclinical
CHEMBL279107 6.58 Kd 260.0 Preclinical
CHEMBL279107 6.52 IC50 300.0 Preclinical
CHEMBL369479 6.21 Kd 620.0 Preclinical
CHEMBL297235 5.82 Kd 1500.0 Preclinical
CHEMBL3752910 5.48 Kd 3279.65 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
3
5.5
1
6.0
5
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
9
Tested Compounds
1
Assay Types
Binding — 5 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 8 6.3
cell-based format 1 1 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine