Cystic fibrosis transmembrane conductance regulator · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Cystic fibrosis transmembrane conductance regulator shows approved-linked disease relevance led by cystic fibrosis. 5 more disease programs remain visible in the same review block. 11 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P13569. Start with cystic fibrosis, then reuse UniProt P13569 as the stable protein anchor across project notes and exports.
Start with cystic fibrosis, then reuse UniProt P13569 as the stable protein anchor across project notes and exports.
Cystic fibrosis transmembrane conductance regulator shows approved-linked disease relevance led by cystic fibrosis. 5 more disease programs remain visible in the same review block. 11 linked drugs remain visible in the same block.
Start review with cystic fibrosis because it currently carries approved-linked support. Linked drugs include BAMOCAFTOR, DEUTIVACAFTOR, ELEXACAFTOR, GALICAFTOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCystic fibrosis transmembrane conductance regulator
Review this target as Cystic fibrosis transmembrane conductance regulator, mapped to UniProt P13569. Sequence length is 1480 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cystic fibrosis transmembrane conductance regulator as ChEMBL target CHEMBL4051, mapped to UniProt P13569. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Cystic fibrosis transmembrane conductance regulator is the right protein anchor across sources, using UniProt P13569 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cystic fibrosis is currently framed as approved-linked support. It currently carries 11 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Cystic fibrosis transmembrane conductance regulator |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P13569 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cystic fibrosis transmembrane conductance regulator |
| UniProt Accession | P13569 |
| Component Type | Protein |
| Sequence Length | 1480 aa |
Cystic fibrosis transmembrane conductance regulator
Review this target as Cystic fibrosis transmembrane conductance regulator, mapped to UniProt P13569. Sequence length is 1480 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cystic fibrosis transmembrane conductance regulator shows approved-linked disease relevance led by cystic fibrosis. 5 more disease programs remain visible in the same review block.
Start review with cystic fibrosis because it currently carries approved-linked support. Linked drugs include BAMOCAFTOR, DEUTIVACAFTOR, ELEXACAFTOR, GALICAFTOR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5863288 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL5178232 | 9.4 | EC50 | 0.4 | Preclinical |
| CHEMBL5861582 | 9.4 | EC50 | 0.4 | Preclinical |
| CHEMBL5802461 | 9.39 | EC50 | 0.41 | Preclinical |
| CHEMBL5892004 | 9.38 | EC50 | 0.42 | Preclinical |
| CHEMBL6033456 | 9.38 | EC50 | 0.42 | Preclinical |
| CHEMBL4558190 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL5193680 | 9.29 | EC50 | 0.51 | Preclinical |
| CHEMBL4084934 | 9.27 | EC50 | 0.54 | Preclinical |
| CHEMBL6009312 | 9.24 | EC50 | 0.57 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 368 | 742 | 6.2 |
| cell membrane format | 35 | 5 | 5.4 |
| single protein format | 28 | 38 | 6.0 |
| assay format | 21 | 59 | 7.6 |
| tissue-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 67 | 6.9 |
| assay format | 6 | 10 | 4.9 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |