Sodium- and chloride-dependent GABA transporter 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P23978. Use UniProt P23978 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P23978 as the stable identity anchor, then attach disease evidence before program review.
Sodium- and chloride-dependent GABA transporter 1
Review this target as Sodium- and chloride-dependent GABA transporter 1, mapped to UniProt P23978. Sequence length is 599 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium- and chloride-dependent GABA transporter 1 as ChEMBL target CHEMBL4054, mapped to UniProt P23978. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sodium- and chloride-dependent GABA transporter 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P23978 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium- and chloride-dependent GABA transporter 1 |
| UniProt Accession | P23978 |
| Component Type | Protein |
| Sequence Length | 599 aa |
Sodium- and chloride-dependent GABA transporter 1
Review this target as Sodium- and chloride-dependent GABA transporter 1, mapped to UniProt P23978. Sequence length is 599 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1195284 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL540827 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL545511 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL545516 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL5205864 | 7.85 | Ki | 14.0 | Preclinical |
| CHEMBL554210 | 7.85 | Ki | 14.0 | Preclinical |
| CHEMBL543880 | 7.77 | Ki | 17.0 | Preclinical |
| CHEMBL554050 | 7.72 | Ki | 19.0 | Preclinical |
| CHEMBL554435 | 7.72 | Ki | 19.0 | Preclinical |
| CHEMBL544586 | 7.68 | Ki | 21.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 15 | 7 | 5.6 |
| subcellular format | 6 | 99 | 6.8 |
| cell-based format | 2 | 2 | 5.5 |
| tissue-based format | 2 | 3 | 7.2 |