Calpain-1 catalytic subunit · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-14Protein identity stays anchored to UniProt P35750. Use UniProt P35750 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35750 as the stable identity anchor, then attach disease evidence before program review.
Calpain-1 catalytic subunit
Review this target as Calpain-1 catalytic subunit, mapped to UniProt P35750. Sequence length is 714 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Calpain-1 catalytic subunit as ChEMBL target CHEMBL4062, mapped to UniProt P35750. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Calpain-1 catalytic subunit is the right protein anchor across sources, using UniProt P35750 as the stable mapping.
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| Preferred Name | Calpain-1 catalytic subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P35750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calpain-1 catalytic subunit |
| UniProt Accession | P35750 |
| Component Type | Protein |
| Sequence Length | 714 aa |
Calpain-1 catalytic subunit
Review this target as Calpain-1 catalytic subunit, mapped to UniProt P35750. Sequence length is 714 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3221946 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3221935 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3221938 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3221942 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL288365 | 8.12 | IC50 | 7.5 | Preclinical |
| CHEMBL480969 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL4647187 | 8.05 | Ki | 9.0 | Preclinical |
| CHEMBL206243 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL286722 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL3221933 | 8.0 | IC50 | 10.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 144 | 6.5 |
| cell-based format | 1 | 6 | 7.7 |