cAMP-dependent protein kinase catalytic subunit alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P17612. Use UniProt P17612 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17612 as the stable identity anchor, then attach disease evidence before program review.
cAMP-dependent protein kinase catalytic subunit alpha
Review this target as cAMP-dependent protein kinase catalytic subunit alpha, mapped to UniProt P17612. Sequence length is 351 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cAMP-dependent protein kinase catalytic subunit alpha as ChEMBL target CHEMBL4101, mapped to UniProt P17612. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cAMP-dependent protein kinase catalytic subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P17612 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cAMP-dependent protein kinase catalytic subunit alpha |
| UniProt Accession | P17612 |
| Component Type | Protein |
| Sequence Length | 351 aa |
cAMP-dependent protein kinase catalytic subunit alpha
Review this target as cAMP-dependent protein kinase catalytic subunit alpha, mapped to UniProt P17612. Sequence length is 351 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5201435 | 10.72 | Kd | 0.019 | Preclinical |
| CHEMBL5179794 | 10.64 | Ki | 0.023 | Preclinical |
| CHEMBL5185265 | 10.38 | Kd | 0.042 | Preclinical |
| CHEMBL524516 | 9.3 | Kd | 0.5 | Preclinical |
| CHEMBL5174535 | 9.2 | Ki | 0.63 | Preclinical |
| CHEMBL5189362 | 9.2 | Kd | 0.63 | Preclinical |
| CHEMBL1980995 | 9.1 | Ki | 0.7943 | Preclinical |
| CHEMBL388978 | 9.03 | IC50 | 0.935 | Preclinical |
| CHEMBL1980407 | 8.9 | Ki | 1.259 | Preclinical |
| CHEMBL498924 | 8.74 | Kd | 1.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 265 | 156 | 6.4 |
| assay format | 66 | 14 | 6.5 |
| cell-based format | 14 | 1 | — |
| subcellular format | 13 | 10 | 6.5 |
| biochemical format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 392 | 6.3 |