Dynamin-like GTPase OPA1, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O60313. Use UniProt O60313 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60313 as the stable identity anchor, then attach disease evidence before program review.
Dynamin-like GTPase OPA1, mitochondrial
Review this target as Dynamin-like GTPase OPA1, mitochondrial, mapped to UniProt O60313. Sequence length is 960 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dynamin-like GTPase OPA1, mitochondrial as ChEMBL target CHEMBL4105705, mapped to UniProt O60313. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dynamin-like GTPase OPA1, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O60313 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dynamin-like GTPase OPA1, mitochondrial |
| UniProt Accession | O60313 |
| Component Type | Protein |
| Sequence Length | 960 aa |
Dynamin-like GTPase OPA1, mitochondrial
Review this target as Dynamin-like GTPase OPA1, mitochondrial, mapped to UniProt O60313. Sequence length is 960 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2103882 | 7.77 | Kd | 17.0 | Clinical |
| CHEMBL5653589 | 7.14 | Kd | 72.92 | Preclinical |
| CHEMBL3752910 | 6.55 | Kd | 280.41 | Preclinical |
| CHEMBL1078178 | 6.15 | Kd | 705.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 2 | 6.8 |
| subcellular format | 1 | 2 | 7.0 |