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Target Snapshot

CHEMBL4105706 Target Snapshot

Membrane-associated progesterone receptor component 1 · SINGLE PROTEIN · Homo sapiens

181Compounds
4Assays
1Approved Drugs
180.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O00264. Use UniProt O00264 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O00264 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Membrane-associated progesterone receptor component 1 as ChEMBL target CHEMBL4105706, mapped to UniProt O00264. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Membrane-associated progesterone receptor component 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4105706
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O00264
Membrane-associated progesterone receptor component 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Membrane-associated progesterone receptor component 1 is the right protein anchor across sources, using UniProt O00264 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMembrane-associated progesterone receptor component 1
UniProt AccessionO00264
Component TypeProtein
Sequence Length195 aa

Membrane-associated progesterone receptor component 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Membrane-associated progesterone receptor component 1, mapped to UniProt O00264. Sequence length is 195 aa.

Mapped IDO00264
Review nameMembrane-associated progesterone receptor component 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KD180.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3301612 6.69 Kd 204.0 Approved
CHEMBL3752910 6.19 Kd 651.37 Preclinical
CHEMBL5653589 4.63 Kd 23190.18 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ENCORAFENIB
CHEMBL3301612
Approved 2018
Assay Landscape

Assay Landscape

4
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0
single protein format 1 2 5.4
subcellular format 1 1 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine