Cyclic GMP-AMP synthase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8N884. Use UniProt Q8N884 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8N884 as the stable identity anchor, then attach disease evidence before program review.
Cyclic GMP-AMP synthase
Review this target as Cyclic GMP-AMP synthase, mapped to UniProt Q8N884. Sequence length is 522 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclic GMP-AMP synthase as ChEMBL target CHEMBL4105728, mapped to UniProt Q8N884. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cyclic GMP-AMP synthase is the right protein anchor across sources, using UniProt Q8N884 as the stable mapping.
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| Preferred Name | Cyclic GMP-AMP synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8N884 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclic GMP-AMP synthase |
| UniProt Accession | Q8N884 |
| Component Type | Protein |
| Sequence Length | 522 aa |
Cyclic GMP-AMP synthase
Review this target as Cyclic GMP-AMP synthase, mapped to UniProt Q8N884. Sequence length is 522 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5612485 | 9.36 | IC50 | 0.44 | Preclinical |
| CHEMBL5614320 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL5620249 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5641551 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL5612416 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL5614182 | 8.55 | IC50 | 2.8 | Preclinical |
| CHEMBL5613252 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL323197 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5619434 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL5573599 | 8.22 | IC50 | 6.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 26 | 208 | 5.6 |
| single protein format | 24 | 28 | 7.0 |
| assay format | 8 | 19 | 7.5 |
| tissue-based format | 1 | 10 | 7.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |