Meprin A subunit alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q16819. Use UniProt Q16819 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16819 as the stable identity anchor, then attach disease evidence before program review.
Meprin A subunit alpha
Review this target as Meprin A subunit alpha, mapped to UniProt Q16819. Sequence length is 746 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Meprin A subunit alpha as ChEMBL target CHEMBL4105775, mapped to UniProt Q16819. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Meprin A subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16819 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Meprin A subunit alpha |
| UniProt Accession | Q16819 |
| Component Type | Protein |
| Sequence Length | 746 aa |
Meprin A subunit alpha
Review this target as Meprin A subunit alpha, mapped to UniProt Q16819. Sequence length is 746 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4205925 | 6.43 | IC50 | 368.0 | Preclinical |
| CHEMBL4209993 | 6.2 | IC50 | 626.0 | Preclinical |
| CHEMBL4217178 | 6.08 | IC50 | 830.0 | Preclinical |
| CHEMBL4203115 | 5.83 | IC50 | 1470.0 | Preclinical |
| CHEMBL4206683 | 5.75 | IC50 | 1795.0 | Preclinical |
| CHEMBL4078433 | 5.48 | IC50 | 3290.0 | Preclinical |
| CHEMBL4217240 | 5.47 | IC50 | 3420.0 | Preclinical |
| CHEMBL4216076 | 4.79 | IC50 | 16050.0 | Preclinical |
| CHEMBL4105563 | 4.56 | IC50 | 27350.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 7 | 5.5 |
| single protein format | 1 | 2 | 6.0 |