Envelope glycoprotein · SINGLE PROTEIN · Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
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As of 2026-09-14Envelope glycoprotein shows approved-linked disease relevance led by Ebola hemorrhagic fever. 2 more disease programs remain visible in the same review block. 10 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q05320. Start with Ebola hemorrhagic fever, then reuse UniProt Q05320 as the stable protein anchor across project notes and exports.
Start with Ebola hemorrhagic fever, then reuse UniProt Q05320 as the stable protein anchor across project notes and exports.
Envelope glycoprotein shows approved-linked disease relevance led by Ebola hemorrhagic fever. 2 more disease programs remain visible in the same review block. 10 linked drugs remain visible in the same block.
Start review with Ebola hemorrhagic fever because it currently carries approved-linked support. Linked drugs include ADENOVIRUS TYPE 26 ENCODING EBOLA VIRUS GLYCOPROTEIN, ANSUVIMAB, ATOLTIVIMAB, COSFROVIXIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEnvelope glycoprotein
Review this target as Envelope glycoprotein, mapped to UniProt Q05320. Sequence length is 676 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Envelope glycoprotein as ChEMBL target CHEMBL4105829, mapped to UniProt Q05320. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Envelope glycoprotein is the right protein anchor across sources, using UniProt Q05320 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Ebola hemorrhagic fever is currently framed as approved-linked support. It currently carries 10 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Envelope glycoprotein |
| Target Type | SINGLE PROTEIN |
| Organism | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) |
| UniProt | Q05320 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Envelope glycoprotein |
| UniProt Accession | Q05320 |
| Component Type | Protein |
| Sequence Length | 676 aa |
Envelope glycoprotein
Review this target as Envelope glycoprotein, mapped to UniProt Q05320. Sequence length is 676 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Envelope glycoprotein shows approved-linked disease relevance led by Ebola hemorrhagic fever. 2 more disease programs remain visible in the same review block.
Start review with Ebola hemorrhagic fever because it currently carries approved-linked support. Linked drugs include ADENOVIRUS TYPE 26 ENCODING EBOLA VIRUS GLYCOPROTEIN, ANSUVIMAB, ATOLTIVIMAB, COSFROVIXIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1655 | 7.2 | EC50 | 62.8 | Approved |
| CHEMBL4206744 | 5.99 | EC50 | 1020.0 | Preclinical |
| CHEMBL1655 | 4.8 | Kd | 16000.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 4 | 6.3 |
| single protein format | 2 | 5 | 4.8 |