Sigma intracellular receptor 2 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q5U3Y7. Use UniProt Q5U3Y7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5U3Y7 as the stable identity anchor, then attach disease evidence before program review.
Sigma intracellular receptor 2
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q5U3Y7. Sequence length is 176 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sigma intracellular receptor 2 as ChEMBL target CHEMBL4105864, mapped to UniProt Q5U3Y7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sigma intracellular receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q5U3Y7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sigma intracellular receptor 2 |
| UniProt Accession | Q5U3Y7 |
| Component Type | Protein |
| Sequence Length | 176 aa |
Sigma intracellular receptor 2
Review this target as Sigma intracellular receptor 2, mapped to UniProt Q5U3Y7. Sequence length is 176 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL61479 | 9.92 | Ki | 0.12 | Clinical |
| CHEMBL53325 | 9.47 | Ki | 0.34 | Preclinical |
| CHEMBL4744466 | 9.42 | Ki | 0.38 | Preclinical |
| CHEMBL5271751 | 9.37 | Ki | 0.43 | Preclinical |
| CHEMBL4531345 | 9.18 | Ki | 0.66 | Preclinical |
| CHEMBL4746910 | 8.88 | Ki | 1.33 | Preclinical |
| CHEMBL4581662 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL4542088 | 8.74 | Ki | 1.81 | Preclinical |
| CHEMBL4584941 | 8.69 | Ki | 2.05 | Preclinical |
| CHEMBL4740593 | 8.68 | Ki | 2.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 75 | 537 | 6.9 |
| cell-based format | 10 | 91 | 7.3 |
| tissue-based format | 8 | 66 | 7.3 |
| assay format | 3 | 35 | 6.6 |
| single protein format | 3 | 2 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 24 | 6.6 |