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Target Snapshot

CHEMBL4105888 Target Snapshot

Myosin-14 · SINGLE PROTEIN · Homo sapiens

217Compounds
1Assays
1Approved Drugs
217.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q7Z406. Use UniProt Q7Z406 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q7Z406 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Myosin-14 as ChEMBL target CHEMBL4105888, mapped to UniProt Q7Z406. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Myosin-14
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4105888
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q7Z406
Myosin-14
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Myosin-14 is the right protein anchor across sources, using UniProt Q7Z406 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMyosin-14
UniProt AccessionQ7Z406
Component TypeProtein
Sequence Length1995 aa

Myosin-14

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Myosin-14, mapped to UniProt Q7Z406. Sequence length is 1995 aa.

Mapped IDQ7Z406
Review nameMyosin-14
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KD217.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3989868 6.73 Kd 188.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TUCATINIB
CHEMBL3989868
Approved 2020
Assay Landscape

Assay Landscape

1
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
subcellular format 1 1 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine