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Target Snapshot

CHEMBL4105929 Target Snapshot

L-lactate dehydrogenase · SINGLE PROTEIN · Homo sapiens

93Compounds
16Assays
0Approved Drugs
49.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt V9HWB9. Use UniProt V9HWB9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt V9HWB9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L-lactate dehydrogenase as ChEMBL target CHEMBL4105929, mapped to UniProt V9HWB9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L-lactate dehydrogenase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4105929
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
V9HWB9
L-lactate dehydrogenase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L-lactate dehydrogenase is the right protein anchor across sources, using UniProt V9HWB9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelL-lactate dehydrogenase
UniProt AccessionV9HWB9
Component TypeProtein
Sequence Length332 aa

L-lactate dehydrogenase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as L-lactate dehydrogenase, mapped to UniProt V9HWB9. Sequence length is 332 aa.

Mapped IDV9HWB9
Review nameL-lactate dehydrogenase
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5049.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4081890 6.29 IC50 517.0 Preclinical
CHEMBL4065858 6.06 IC50 877.0 Preclinical
CHEMBL4100845 6.01 IC50 983.0 Preclinical
CHEMBL4082867 5.72 IC50 1920.0 Preclinical
CHEMBL4059985 5.47 IC50 3370.0 Preclinical
CHEMBL4101800 5.36 IC50 4350.0 Preclinical
CHEMBL4076027 5.14 IC50 7240.0 Preclinical
CHEMBL4075666 5.03 IC50 9450.0 Preclinical
CHEMBL4080497 5.0 IC50 9880.0 Preclinical
CHEMBL3335794 4.9 IC50 12600.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
4
5.5
4
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
18
Tested Compounds
3
Assay Types
Binding — 15 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 18 5.1
single protein format 4 0
assay format 3 0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine