2-amino-3-carboxymuconate-6-semialdehyde decarboxylase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8TDX5. Use UniProt Q8TDX5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8TDX5 as the stable identity anchor, then attach disease evidence before program review.
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Review this target as 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, mapped to UniProt Q8TDX5. Sequence length is 336 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase as ChEMBL target CHEMBL4105941, mapped to UniProt Q8TDX5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8TDX5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| UniProt Accession | Q8TDX5 |
| Component Type | Protein |
| Sequence Length | 336 aa |
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Review this target as 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, mapped to UniProt Q8TDX5. Sequence length is 336 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4072240 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4071212 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4100715 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4796997 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL4553502 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL4578242 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL4067706 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL4437596 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL4580504 | 7.18 | IC50 | 66.0 | Preclinical |
| CHEMBL4097581 | 7.15 | IC50 | 71.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 32 | 6.9 |
| single protein format | 6 | 17 | 5.3 |
| assay format | 2 | 25 | 6.8 |