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Target Snapshot

CHEMBL4105966 Target Snapshot

Glucocorticoid receptor · SINGLE PROTEIN · Canis lupus familiaris

3Compounds
4Assays
1Approved Drugs
6.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt A0A8C0QLS2. Use UniProt A0A8C0QLS2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A0A8C0QLS2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glucocorticoid receptor as ChEMBL target CHEMBL4105966, mapped to UniProt A0A8C0QLS2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glucocorticoid receptor
SINGLE PROTEIN · Canis lupus familiaris
As of 2026-09-14
ChEMBL target ID
CHEMBL4105966
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
A0A8C0QLS2
Glucocorticoid receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glucocorticoid receptor is the right protein anchor across sources, using UniProt A0A8C0QLS2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlucocorticoid receptor
UniProt AccessionA0A8C0QLS2
Component TypeProtein
Sequence Length781 aa

Glucocorticoid receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glucocorticoid receptor, mapped to UniProt A0A8C0QLS2. Sequence length is 781 aa.

Mapped IDA0A8C0QLS2
Review nameGlucocorticoid receptor
OrganismCanis lupus familiaris
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC504.0
KI1.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1276308 7.7 IC50 20.2 Approved
CHEMBL4161754 7.61 IC50 24.5 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
2
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIFEPRISTONE
CHEMBL1276308
Approved 2000
Assay Landscape

Assay Landscape

4
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 4 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 2 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine