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Target Snapshot

CHEMBL4105975 Target Snapshot

Cytochrome c1, heme protein, mitochondrial · SINGLE PROTEIN · Homo sapiens

238Compounds
2Assays
1Approved Drugs
238.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P08574. Use UniProt P08574 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P08574 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome c1, heme protein, mitochondrial as ChEMBL target CHEMBL4105975, mapped to UniProt P08574. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome c1, heme protein, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4105975
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08574
Cytochrome c1, heme protein, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome c1, heme protein, mitochondrial is the right protein anchor across sources, using UniProt P08574 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome c1, heme protein, mitochondrial
UniProt AccessionP08574
Component TypeProtein
Sequence Length325 aa

Cytochrome c1, heme protein, mitochondrial

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cytochrome c1, heme protein, mitochondrial, mapped to UniProt P08574. Sequence length is 325 aa.

Mapped IDP08574
Review nameCytochrome c1, heme protein, mitochondrial
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KD238.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3752910 9.26 Kd 0.55 Preclinical
CHEMBL5653589 7.53 Kd 29.28 Preclinical
CHEMBL3301622 6.7 Kd 202.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GILTERITINIB
CHEMBL3301622
Approved 2018
Assay Landscape

Assay Landscape

2
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 2 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 2 8.4
subcellular format 1 1 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine