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Target Snapshot

CHEMBL4105981 Target Snapshot

Protein mono-ADP-ribosyltransferase PARP16 · SINGLE PROTEIN · Homo sapiens

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41Compounds
15Assays
3Approved Drugs
48.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q8N5Y8. Use UniProt Q8N5Y8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8N5Y8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein mono-ADP-ribosyltransferase PARP16 as ChEMBL target CHEMBL4105981, mapped to UniProt Q8N5Y8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein mono-ADP-ribosyltransferase PARP16
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4105981
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8N5Y8
Protein mono-ADP-ribosyltransferase PARP16
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein mono-ADP-ribosyltransferase PARP16 is the right protein anchor across sources, using UniProt Q8N5Y8 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProtein mono-ADP-ribosyltransferase PARP16
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ8N5Y8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein mono-ADP-ribosyltransferase PARP16
UniProt AccessionQ8N5Y8
Component TypeProtein
Sequence Length322 aa

Protein mono-ADP-ribosyltransferase PARP16

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Protein mono-ADP-ribosyltransferase PARP16, mapped to UniProt Q8N5Y8. Sequence length is 322 aa.

Mapped IDQ8N5Y8
Review nameProtein mono-ADP-ribosyltransferase PARP16
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5041.0
KD7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3752910 8.8 Kd 1.6 Preclinical
CHEMBL5189477 6.44 IC50 362.0 Preclinical
CHEMBL5284069 6.44 IC50 362.0 Preclinical
CHEMBL5172255 6.37 IC50 427.0 Preclinical
CHEMBL4089522 6.25 IC50 560.0 Preclinical
CHEMBL3137320 6.0 Kd 1000.0 Approved
CHEMBL3764816 5.73 IC50 1862.09 Preclinical
CHEMBL1173055 5.54 Kd 2900.0 Approved
CHEMBL5404785 5.47 IC50 3400.0 Preclinical
CHEMBL1438938 5.38 IC50 4200.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
3
5.5
6
6.0
0
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TALAZOPARIB
CHEMBL3137320
Approved 2018
Properties Compare Identifier
Assay Landscape

Assay Landscape

15
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 15 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 11 10 6.3
assay format 4 6 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine