Cathepsin D · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P80209. Use UniProt P80209 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P80209 as the stable identity anchor, then attach disease evidence before program review.
Cathepsin D
Review this target as Cathepsin D, mapped to UniProt P80209. Sequence length is 390 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cathepsin D as ChEMBL target CHEMBL4106, mapped to UniProt P80209. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cathepsin D is the right protein anchor across sources, using UniProt P80209 as the stable mapping.
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| Preferred Name | Cathepsin D |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P80209 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cathepsin D |
| UniProt Accession | P80209 |
| Component Type | Protein |
| Sequence Length | 390 aa |
Cathepsin D
Review this target as Cathepsin D, mapped to UniProt P80209. Sequence length is 390 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL296588 | 9.3 | Ki | 0.5 | Clinical |
| CHEMBL3392098 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL164716 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL3142508 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL154795 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL3392096 | 8.68 | Ki | 2.1 | Preclinical |
| CHEMBL164635 | 8.43 | Ki | 3.7 | Preclinical |
| CHEMBL3142505 | 8.24 | Ki | 5.8 | Preclinical |
| CHEMBL362209 | 8.2 | IC50 | 6.3 | Preclinical |
| CHEMBL407670 | 8.15 | IC50 | 7.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 59 | 162 | 6.4 |
| tissue-based format | 2 | 44 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 1 | 1 | 7.2 |