DNA-PK/Ku70/Ku85 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P78527. Use UniProt P78527 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P78527 as the stable identity anchor, then attach disease evidence before program review.
DNA-dependent protein kinase catalytic subunit
Review this target as DNA-PK/Ku70/Ku85, mapped to UniProt P78527. ChEMBL maps the protein component as DNA-dependent protein kinase catalytic subunit. Sequence length is 4128 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA-PK/Ku70/Ku85 as ChEMBL target CHEMBL4106136, mapped to UniProt P78527. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA-PK/Ku70/Ku85 is the right protein anchor across sources, using UniProt P78527 as the stable mapping.
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| Preferred Name | DNA-PK/Ku70/Ku85 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P78527 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA-dependent protein kinase catalytic subunit |
| UniProt Accession | P78527 |
| Component Type | Protein |
| Sequence Length | 4128 aa |
DNA-dependent protein kinase catalytic subunit
Review this target as DNA-PK/Ku70/Ku85, mapped to UniProt P78527. ChEMBL maps the protein component as DNA-dependent protein kinase catalytic subunit. Sequence length is 4128 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1795743 | 5.0 | IC50 | 10000.0 | Preclinical |
| CHEMBL3915703 | 4.92 | IC50 | 11900.0 | Preclinical |
| CHEMBL175883 | 4.9 | IC50 | 12500.0 | Preclinical |
| CHEMBL1795742 | 4.41 | IC50 | 38800.0 | Preclinical |
| CHEMBL3945937 | 4.11 | IC50 | 78100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 0 | — |
| protein complex format | 9 | 0 | — |
| subcellular format | 7 | 0 | — |
| assay format | 2 | 5 | 4.7 |