ATR/ATRIP · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q13535. Use UniProt Q13535 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13535 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase ATR
Review this target as ATR/ATRIP, mapped to UniProt Q13535. ChEMBL maps the protein component as Serine/threonine-protein kinase ATR. Sequence length is 2644 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats ATR/ATRIP as ChEMBL target CHEMBL4106138, mapped to UniProt Q13535. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether ATR/ATRIP is the right protein anchor across sources, using UniProt Q13535 as the stable mapping.
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| Preferred Name | ATR/ATRIP |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q13535 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase ATR |
| UniProt Accession | Q13535 |
| Component Type | Protein |
| Sequence Length | 2644 aa |
Serine/threonine-protein kinase ATR
Review this target as ATR/ATRIP, mapped to UniProt Q13535. ChEMBL maps the protein component as Serine/threonine-protein kinase ATR. Sequence length is 2644 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5783158 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5786594 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5800832 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL5800499 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL5761609 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL5928836 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL4293269 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5790125 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5957036 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5549943 | 8.8 | IC50 | 1.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 21 | 491 | 7.1 |
| cell-based format | 5 | 255 | 6.7 |
| assay format | 2 | 7 | 8.2 |