METTL3/METTL14 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q86U44. Use UniProt Q86U44 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q86U44 as the stable identity anchor, then attach disease evidence before program review.
N(6)-adenosine-methyltransferase catalytic subunit METTL3
Review this target as METTL3/METTL14, mapped to UniProt Q86U44. ChEMBL maps the protein component as N(6)-adenosine-methyltransferase catalytic subunit METTL3. Sequence length is 580 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats METTL3/METTL14 as ChEMBL target CHEMBL4106140, mapped to UniProt Q86U44. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether METTL3/METTL14 is the right protein anchor across sources, using UniProt Q86U44 as the stable mapping.
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| Preferred Name | METTL3/METTL14 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q86U44 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | N(6)-adenosine-methyltransferase catalytic subunit METTL3 |
| UniProt Accession | Q86U44 |
| Component Type | Protein |
| Sequence Length | 580 aa |
N(6)-adenosine-methyltransferase catalytic subunit METTL3
Review this target as METTL3/METTL14, mapped to UniProt Q86U44. ChEMBL maps the protein component as N(6)-adenosine-methyltransferase catalytic subunit METTL3. Sequence length is 580 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5291234 | 8.85 | Kd | 1.4 | Preclinical |
| CHEMBL5396973 | 8.44 | IC50 | 3.63 | Preclinical |
| CHEMBL5076382 | 8.42 | IC50 | 3.84 | Preclinical |
| CHEMBL5405105 | 8.36 | IC50 | 4.35 | Preclinical |
| CHEMBL5071936 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL5072426 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL5074655 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL5075067 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL5075128 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL5075825 | 8.21 | IC50 | 6.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 24 | 19 | 5.7 |
| cell-based format | 7 | 11 | 5.0 |
| assay format | 6 | 165 | 7.7 |