N-type calcium channel alpha-1b/alpha2delta-1/beta-1b · PROTEIN COMPLEX · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P54289. Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as N-type calcium channel alpha-1b/alpha2delta-1/beta-1b, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats N-type calcium channel alpha-1b/alpha2delta-1/beta-1b as ChEMBL target CHEMBL4106160, mapped to UniProt P54289. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether N-type calcium channel alpha-1b/alpha2delta-1/beta-1b is the right protein anchor across sources, using UniProt P54289 as the stable mapping.
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| Preferred Name | N-type calcium channel alpha-1b/alpha2delta-1/beta-1b |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P54289 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| UniProt Accession | P54289 |
| Component Type | Protein |
| Sequence Length | 1103 aa |
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as N-type calcium channel alpha-1b/alpha2delta-1/beta-1b, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL597782 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL599404 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL599402 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL605965 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL599829 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL597585 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL598592 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL597783 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL596946 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL597788 | 6.96 | IC50 | 110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 48 | 6.6 |