Use UniProt Q15759 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4106180 Target Snapshot
p38 MAP kinase alpha/beta · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15759. Use UniProt Q15759 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 11
Review this target as p38 MAP kinase alpha/beta, mapped to UniProt Q15759. ChEMBL maps the protein component as Mitogen-activated protein kinase 11. Sequence length is 364 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats p38 MAP kinase alpha/beta as ChEMBL target CHEMBL4106180, mapped to UniProt Q15759. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether p38 MAP kinase alpha/beta is the right protein anchor across sources, using UniProt Q15759 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | p38 MAP kinase alpha/beta |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q15759 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 11 |
| UniProt Accession | Q15759 |
| Component Type | Protein |
| Sequence Length | 364 aa |
Mitogen-activated protein kinase 11
How to read this target
Review this target as p38 MAP kinase alpha/beta, mapped to UniProt Q15759. ChEMBL maps the protein component as Mitogen-activated protein kinase 11. Sequence length is 364 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL278041 | 6.52 | IC50 | 300.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 2 assays, 1 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 2 | 1 | 6.5 |