Glutamate receptor ionotropic, NMDA 2C · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q14957. Use UniProt Q14957 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14957 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 2C
Review this target as Glutamate receptor ionotropic, NMDA 2C, mapped to UniProt Q14957. Sequence length is 1233 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, NMDA 2C as ChEMBL target CHEMBL4109, mapped to UniProt Q14957. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Glutamate receptor ionotropic, NMDA 2C is the right protein anchor across sources, using UniProt Q14957 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Glutamate receptor ionotropic, NMDA 2C |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14957 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 2C |
| UniProt Accession | Q14957 |
| Component Type | Protein |
| Sequence Length | 1233 aa |
Glutamate receptor ionotropic, NMDA 2C
Review this target as Glutamate receptor ionotropic, NMDA 2C, mapped to UniProt Q14957. Sequence length is 1233 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2397256 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL2397103 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL2397257 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL2397119 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL5273123 | 5.72 | EC50 | 1900.0 | Preclinical |
| CHEMBL2397109 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL2397211 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL4464605 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL2397093 | 5.62 | IC50 | 2400.0 | Preclinical |
| CHEMBL4544421 | 5.58 | IC50 | 2600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 51 | 5.0 |
| single protein format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 4.3 |