Beta-lactamase · SINGLE PROTEIN · Staphylococcus aureus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P00807. Use UniProt P00807 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00807 as the stable identity anchor, then attach disease evidence before program review.
Beta-lactamase
Review this target as Beta-lactamase, mapped to UniProt P00807. Sequence length is 281 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-lactamase as ChEMBL target CHEMBL4114, mapped to UniProt P00807. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Beta-lactamase is the right protein anchor across sources, using UniProt P00807 as the stable mapping.
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| Preferred Name | Beta-lactamase |
| Target Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
| UniProt | P00807 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-lactamase |
| UniProt Accession | P00807 |
| Component Type | Protein |
| Sequence Length | 281 aa |
Beta-lactamase
Review this target as Beta-lactamase, mapped to UniProt P00807. Sequence length is 281 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL294608 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL294203 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL292093 | 7.81 | IC50 | 15.4 | Preclinical |
| CHEMBL303053 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL268919 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL777 | 7.1 | IC50 | 80.0 | Approved |
| CHEMBL353613 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL305361 | 6.98 | IC50 | 105.0 | Preclinical |
| CHEMBL61762 | 6.75 | IC50 | 180.0 | Preclinical |
| CHEMBL64793 | 6.71 | IC50 | 196.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 42 | 55 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 0 | — |