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Target Snapshot

CHEMBL4117 Target Snapshot

Aminopeptidase N · SINGLE PROTEIN · Plasmodium falciparum FcB1/Columbia

868Compounds
8Assays
5Approved Drugs
743.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O96935. Use UniProt O96935 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O96935 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aminopeptidase N as ChEMBL target CHEMBL4117, mapped to UniProt O96935. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aminopeptidase N
SINGLE PROTEIN · Plasmodium falciparum FcB1/Columbia
As of 2026-09-13
ChEMBL target ID
CHEMBL4117
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O96935
Aminopeptidase N
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aminopeptidase N is the right protein anchor across sources, using UniProt O96935 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAminopeptidase N
UniProt AccessionO96935
Component TypeProtein
Sequence Length1085 aa

Aminopeptidase N

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Aminopeptidase N, mapped to UniProt O96935. Sequence length is 1085 aa.

Mapped IDO96935
Review nameAminopeptidase N
OrganismPlasmodium falciparum FcB1/Columbia
Clinical Profile

Clinical Phase Distribution

5
Approved
3
Phase II
Assay Mix

Activity Type Distribution

IC50715.0
KI28.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3359693 9.15 Ki 0.7 Preclinical
CHEMBL3359688 9.1 Ki 0.8 Preclinical
CHEMBL3359696 8.72 Ki 1.9 Preclinical
CHEMBL3359697 8.4 Ki 4.0 Preclinical
CHEMBL3359699 8.26 Ki 5.5 Preclinical
CHEMBL219777 8.22 IC50 6.0 Preclinical
CHEMBL3359700 8.13 Ki 7.4 Preclinical
CHEMBL3359698 7.95 Ki 11.2 Preclinical
CHEMBL3359692 7.91 Ki 12.3 Preclinical
CHEMBL375521 7.89 IC50 13.0 Preclinical
Distribution

pChEMBL Value Distribution

42
5.0
18
5.5
13
6.0
15
6.5
8
7.0
5
7.5
4
8.0
1
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
728
Tested Compounds
1
Assay Types
Binding — 8 assays, 728 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 721 4.7
assay format 1 7 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine