Histamine H3 receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9QYN8. Use UniProt Q9QYN8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9QYN8 as the stable identity anchor, then attach disease evidence before program review.
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9QYN8. Sequence length is 445 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H3 receptor as ChEMBL target CHEMBL4124, mapped to UniProt Q9QYN8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histamine H3 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9QYN8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H3 receptor |
| UniProt Accession | Q9QYN8 |
| Component Type | Protein |
| Sequence Length | 445 aa |
Histamine H3 receptor
Review this target as Histamine H3 receptor, mapped to UniProt Q9QYN8. Sequence length is 445 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2386729 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL2386727 | 10.49 | Ki | 0.032 | Preclinical |
| CHEMBL270011 | 10.35 | Ki | 0.04467 | Preclinical |
| CHEMBL2386728 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL255962 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL408934 | 10.17 | Ki | 0.06761 | Preclinical |
| CHEMBL401954 | 10.11 | Ki | 0.07762 | Preclinical |
| CHEMBL1085337 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL368398 | 10.1 | Ki | 0.07943 | Preclinical |
| CHEMBL402640 | 10.0 | Ki | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 56 | 459 | 7.9 |
| cell-based format | 37 | 326 | 8.0 |
| cell membrane format | 25 | 324 | 7.8 |
| assay format | 24 | 311 | 8.0 |
| subcellular format | 16 | 158 | 7.9 |
| tissue-based format | 16 | 60 | 7.9 |
| organism-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 35 | 24 | 7.6 |
| subcellular format | 28 | 187 | 7.8 |
| tissue-based format | 21 | 31 | 7.3 |
| cell-based format | 12 | 41 | 8.2 |
| cell membrane format | 2 | 5 | 8.7 |