Angiopoietin-1 receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Angiopoietin-1 receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 6 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q02763. Start with cancer, then reuse UniProt Q02763 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt Q02763 as the stable protein anchor across project notes and exports.
Angiopoietin-1 receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block. 6 linked drugs remain visible in the same block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include ALTIRATINIB, CEP-11981, FORETINIB, GLESATINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAngiopoietin-1 receptor
Review this target as Angiopoietin-1 receptor, mapped to UniProt Q02763. Sequence length is 1124 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Angiopoietin-1 receptor as ChEMBL target CHEMBL4128, mapped to UniProt Q02763. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Angiopoietin-1 receptor is the right protein anchor across sources, using UniProt Q02763 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as approved-linked support. It currently carries 6 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Angiopoietin-1 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q02763 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Angiopoietin-1 receptor |
| UniProt Accession | Q02763 |
| Component Type | Protein |
| Sequence Length | 1124 aa |
Angiopoietin-1 receptor
Review this target as Angiopoietin-1 receptor, mapped to UniProt Q02763. Sequence length is 1124 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Angiopoietin-1 receptor shows approved-linked disease relevance led by cancer. 5 more disease programs remain visible in the same review block.
Start review with cancer because it currently carries approved-linked support. Linked drugs include ALTIRATINIB, CEP-11981, FORETINIB, GLESATINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4087541 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL4103584 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL4449700 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL4447552 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL3937186 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3950106 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3967492 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3976004 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4528844 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4452256 | 9.44 | IC50 | 0.36 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 560 | 766 | 6.8 |
| assay format | 68 | 83 | 6.7 |
| cell-based format | 57 | 74 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 28 | 7.1 |
| assay format | 1 | 11 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| cell-based format | 1 | 0 | — |