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Target Snapshot

CHEMBL4137 Target Snapshot

Glyceraldehyde-3-phosphate dehydrogenase, cytosolic · SINGLE PROTEIN · Leishmania mexicana

49Compounds
2Assays
1Approved Drugs
49.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q01558. Use UniProt Q01558 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q01558 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glyceraldehyde-3-phosphate dehydrogenase, cytosolic as ChEMBL target CHEMBL4137, mapped to UniProt Q01558. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
SINGLE PROTEIN · Leishmania mexicana
As of 2026-09-14
ChEMBL target ID
CHEMBL4137
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q01558
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glyceraldehyde-3-phosphate dehydrogenase, cytosolic is the right protein anchor across sources, using UniProt Q01558 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlyceraldehyde-3-phosphate dehydrogenase, cytosolic
UniProt AccessionQ01558
Component TypeProtein
Sequence Length331 aa

Glyceraldehyde-3-phosphate dehydrogenase, cytosolic

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glyceraldehyde-3-phosphate dehydrogenase, cytosolic, mapped to UniProt Q01558. Sequence length is 331 aa.

Mapped IDQ01558
Review nameGlyceraldehyde-3-phosphate dehydrogenase, cytosolic
OrganismLeishmania mexicana
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5049.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL291418 5.7 IC50 2000.0 Preclinical
CHEMBL303342 5.7 IC50 2000.0 Preclinical
CHEMBL303751 5.7 IC50 2000.0 Preclinical
CHEMBL303934 5.7 IC50 2000.0 Preclinical
CHEMBL63338 5.7 IC50 2000.0 Preclinical
CHEMBL43452 5.54 IC50 2900.0 Approved
CHEMBL63569 5.52 IC50 3000.0 Preclinical
CHEMBL303595 5.4 IC50 4000.0 Preclinical
CHEMBL303752 5.4 IC50 4000.0 Preclinical
CHEMBL303730 5.3 IC50 5000.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
7
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
43
Tested Compounds
1
Assay Types
Binding — 2 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 5.5
single protein format 1 42 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine