Use UniProt Q01558 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4137 Target Snapshot
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic · SINGLE PROTEIN · Leishmania mexicana
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As of 2026-09-14Protein identity stays anchored to UniProt Q01558. Use UniProt Q01558 as the stable identity anchor, then attach disease evidence before program review.
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
Review this target as Glyceraldehyde-3-phosphate dehydrogenase, cytosolic, mapped to UniProt Q01558. Sequence length is 331 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Glyceraldehyde-3-phosphate dehydrogenase, cytosolic as ChEMBL target CHEMBL4137, mapped to UniProt Q01558. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glyceraldehyde-3-phosphate dehydrogenase, cytosolic |
| Target Type | SINGLE PROTEIN |
| Organism | Leishmania mexicana |
| UniProt | Q01558 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glyceraldehyde-3-phosphate dehydrogenase, cytosolic |
| UniProt Accession | Q01558 |
| Component Type | Protein |
| Sequence Length | 331 aa |
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic
How to read this target
Review this target as Glyceraldehyde-3-phosphate dehydrogenase, cytosolic, mapped to UniProt Q01558. Sequence length is 331 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL291418 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL303342 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL303751 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL303934 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL63338 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL43452 | 5.54 | IC50 | 2900.0 | Approved |
| CHEMBL63569 | 5.52 | IC50 | 3000.0 | Preclinical |
| CHEMBL303595 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL303752 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL303730 | 5.3 | IC50 | 5000.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 2 assays, 43 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 5.5 |
| single protein format | 1 | 42 | 4.8 |