[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q16654. Use UniProt Q16654 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16654 as the stable identity anchor, then attach disease evidence before program review.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Review this target as [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, mapped to UniProt Q16654. Sequence length is 411 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial as ChEMBL target CHEMBL4141, mapped to UniProt Q16654. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16654 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
| UniProt Accession | Q16654 |
| Component Type | Protein |
| Sequence Length | 411 aa |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Review this target as [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial, mapped to UniProt Q16654. Sequence length is 411 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4591977 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL4551410 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL4519504 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL5087040 | 7.91 | IC50 | 12.2 | Preclinical |
| CHEMBL4575355 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5072731 | 7.75 | IC50 | 17.8 | Preclinical |
| CHEMBL4461160 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL3727577 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL5079107 | 7.62 | IC50 | 24.1 | Preclinical |
| CHEMBL5087238 | 7.48 | IC50 | 32.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 52 | 76 | 6.1 |
| cell-based format | 7 | 2 | 5.7 |
| assay format | 4 | 8 | 5.5 |