Calpain-2 catalytic subunit · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-13Protein identity stays anchored to UniProt P43367. Use UniProt P43367 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P43367 as the stable identity anchor, then attach disease evidence before program review.
Calpain-2 catalytic subunit
Review this target as Calpain-2 catalytic subunit, mapped to UniProt P43367. Sequence length is 324 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Calpain-2 catalytic subunit as ChEMBL target CHEMBL4143, mapped to UniProt P43367. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Calpain-2 catalytic subunit is the right protein anchor across sources, using UniProt P43367 as the stable mapping.
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| Preferred Name | Calpain-2 catalytic subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P43367 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calpain-2 catalytic subunit |
| UniProt Accession | P43367 |
| Component Type | Protein |
| Sequence Length | 324 aa |
Calpain-2 catalytic subunit
Review this target as Calpain-2 catalytic subunit, mapped to UniProt P43367. Sequence length is 324 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4590466 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL209457 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL4540394 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL4574306 | 7.47 | IC50 | 34.0 | Preclinical |
| CHEMBL1242959 | 7.39 | Ki | 41.0 | Preclinical |
| CHEMBL288365 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL1240872 | 7.17 | Ki | 68.0 | Preclinical |
| CHEMBL1242960 | 7.16 | Ki | 70.0 | Preclinical |
| CHEMBL1240873 | 7.11 | Ki | 77.0 | Preclinical |
| CHEMBL475920 | 7.0 | IC50 | 99.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 23 | 6.6 |
| tissue-based format | 1 | 14 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 828 | 5.1 |