Monoglyceride lipase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Monoglyceride lipase shows clinical signal disease relevance led by tic disorder. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q99685. Start with tic disorder, then reuse UniProt Q99685 as the stable protein anchor across project notes and exports.
Start with tic disorder, then reuse UniProt Q99685 as the stable protein anchor across project notes and exports.
Monoglyceride lipase shows clinical signal disease relevance led by tic disorder. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with tic disorder because it currently carries clinical signal support. Linked drugs include ELCUBRAGISTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMonoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt Q99685. Sequence length is 303 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Monoglyceride lipase as ChEMBL target CHEMBL4191, mapped to UniProt Q99685. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Monoglyceride lipase is the right protein anchor across sources, using UniProt Q99685 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why tic disorder is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Monoglyceride lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99685 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Monoglyceride lipase |
| UniProt Accession | Q99685 |
| Component Type | Protein |
| Sequence Length | 303 aa |
Monoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt Q99685. Sequence length is 303 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Monoglyceride lipase shows clinical signal disease relevance led by tic disorder. 3 more disease programs remain visible in the same review block.
Start review with tic disorder because it currently carries clinical signal support. Linked drugs include ELCUBRAGISTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5785193 | 10.85 | IC50 | 0.014 | Preclinical |
| CHEMBL5283351 | 10.72 | IC50 | 0.019 | Preclinical |
| CHEMBL5569248 | 10.68 | IC50 | 0.021 | Preclinical |
| CHEMBL5074982 | 10.62 | IC50 | 0.024 | Preclinical |
| CHEMBL5832941 | 10.57 | IC50 | 0.027 | Preclinical |
| CHEMBL4749516 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL5618354 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL5282368 | 10.47 | IC50 | 0.034 | Preclinical |
| CHEMBL5892322 | 10.41 | IC50 | 0.039 | Preclinical |
| CHEMBL4759880 | 10.4 | IC50 | 0.04 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 217 | 931 | 6.6 |
| assay format | 63 | 860 | 7.1 |
| cell-based format | 38 | 215 | 7.2 |
| subcellular format | 2 | 34 | 7.7 |
| cell membrane format | 1 | 0 | — |
| organism-based format | 1 | 93 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 1 | 8.8 |