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Target Snapshot

CHEMBL4192 Target Snapshot

Beta-glucosidase · SINGLE PROTEIN · Prunus avium

67Compounds
24Assays
0Approved Drugs
51.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q43014. Use UniProt Q43014 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q43014 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-glucosidase as ChEMBL target CHEMBL4192, mapped to UniProt Q43014. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-glucosidase
SINGLE PROTEIN · Prunus avium
As of 2026-09-14
ChEMBL target ID
CHEMBL4192
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q43014
Beta-glucosidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-glucosidase is the right protein anchor across sources, using UniProt Q43014 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-glucosidase
UniProt AccessionQ43014
Component TypeProtein
Sequence Length531 aa

Beta-glucosidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Beta-glucosidase, mapped to UniProt Q43014. Sequence length is 531 aa.

Mapped IDQ43014
Review nameBeta-glucosidase
OrganismPrunus avium
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC5028.0
KI23.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL157924 6.96 Ki 110.0 Preclinical
CHEMBL307429 5.02 Ki 9500.0 Clinical
CHEMBL313295 4.92 Ki 12000.0 Preclinical
CHEMBL364554 4.92 IC50 12000.0 Preclinical
CHEMBL186291 4.57 IC50 27000.0 Preclinical
CHEMBL83278 4.57 Ki 27000.0 Preclinical
CHEMBL186068 4.47 IC50 34000.0 Preclinical
CHEMBL208021 4.35 Ki 45000.0 Preclinical
CHEMBL2115197 4.28 Ki 53000.0 Preclinical
CHEMBL2207397 4.28 Ki 53000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

24
Total Assays
31
Tested Compounds
1
Assay Types
Binding — 24 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 24 31 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine