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Evidence Snapshot

Dual specificity protein kinase CLK4

CHEMBL4203 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:23Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4203
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dual specificity protein kinase CLK4 as ChEMBL target CHEMBL4203, mapped to UniProt Q9HAZ1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dual specificity protein kinase CLK4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4203
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9HAZ1
Dual specificity protein kinase CLK4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Dual specificity protein kinase CLK4 matters

As of 2026-09-13

Dual specificity protein kinase CLK4 is reviewed as Dual specificity protein kinase CLK4 (UniProt Q9HAZ1); the current evidence base includes 17 approved drugs, 2938 compounds, and 312 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 17 approved drugs, 2938 compounds, and 312 assays for this target. The dominant activity type is KI. CHEMBL1980407 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL1980407 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
17 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Dual specificity protein kinase CLK4 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9HAZ1, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2938
Total Compounds
312
Total Assays
17
Approved Drugs
IC50: 718.0, KI: 1017.0, EC50: 2.0, KD: 323.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL1980407
 9.5 Ki —
No preferred name
CHEMBL379218
 9.3 Kd —
No preferred name
CHEMBL4797564
 9.2 IC50 —
No preferred name
CHEMBL4797564
 9.2 Kd —
No preferred name
CHEMBL2007574
 9.2 Ki —

Approved Drugs

Structure Compound First Approval
CAPIVASERTIB
CHEMBL2325741
 2023
ENTRECTINIB
CHEMBL1983268
 2019
ABEMACICLIB
CHEMBL3301610
 2017
MIDOSTAURIN
CHEMBL608533
 2017
PALBOCICLIB
CHEMBL189963
 2015
NINTEDANIB
CHEMBL502835
 2014
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:44:23Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4203