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Target Snapshot

CHEMBL4211 Target Snapshot

Carbonic anhydrase · SINGLE PROTEIN · Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)

47Compounds
2Assays
10Approved Drugs
82.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O24855. Use UniProt O24855 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O24855 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Carbonic anhydrase as ChEMBL target CHEMBL4211, mapped to UniProt O24855. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Carbonic anhydrase
SINGLE PROTEIN · Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
As of 2026-09-14
ChEMBL target ID
CHEMBL4211
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O24855
Carbonic anhydrase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Carbonic anhydrase is the right protein anchor across sources, using UniProt O24855 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase
UniProt AccessionO24855
Component TypeProtein
Sequence Length221 aa

Carbonic anhydrase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Carbonic anhydrase, mapped to UniProt O24855. Sequence length is 221 aa.

Mapped IDO24855
Review nameCarbonic anhydrase
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori)
Clinical Profile

Clinical Phase Distribution

10
Approved
2
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

KI82.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL206295 7.92 Ki 12.0 Preclinical
CHEMBL206657 7.89 Ki 13.0 Preclinical
CHEMBL20 7.7 Ki 20.0 Approved
CHEMBL204049 7.57 Ki 27.0 Preclinical
CHEMBL204954 7.51 Ki 31.0 Preclinical
CHEMBL266240 7.39 Ki 41.0 Preclinical
CHEMBL204077 7.29 Ki 51.0 Preclinical
CHEMBL203498 7.22 Ki 60.0 Preclinical
CHEMBL381544 7.21 Ki 62.0 Preclinical
CHEMBL6633 7.14 Ki 72.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
8
5.5
30
6.0
26
6.5
10
7.0
6
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZONISAMIDE
CHEMBL750
Approved 2000
BRINZOLAMIDE
CHEMBL220491
Approved 1998
TOPIRAMATE
CHEMBL220492
Approved 1996
SULFANILAMIDE
CHEMBL21
Approved 1985
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
MAFENIDE
CHEMBL419
Approved 1969
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

2
Total Assays
47
Tested Compounds
1
Assay Types
Binding — 2 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 47 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine