Dual specificity protein kinase CLK1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P49759. Use UniProt P49759 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49759 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity protein kinase CLK1
Review this target as Dual specificity protein kinase CLK1, mapped to UniProt P49759. Sequence length is 484 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity protein kinase CLK1 as ChEMBL target CHEMBL4224, mapped to UniProt P49759. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity protein kinase CLK1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P49759 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity protein kinase CLK1 |
| UniProt Accession | P49759 |
| Component Type | Protein |
| Sequence Length | 484 aa |
Dual specificity protein kinase CLK1
Review this target as Dual specificity protein kinase CLK1, mapped to UniProt P49759. Sequence length is 484 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4784318 | 10.74 | Kd | 0.018 | Preclinical |
| CHEMBL393525 | 10.25 | Kd | 0.056 | Preclinical |
| CHEMBL5653589 | 9.65 | Kd | 0.224 | Preclinical |
| CHEMBL4441878 | 9.64 | Kd | 0.228 | Preclinical |
| CHEMBL4647659 | 9.6 | Kd | 0.254 | Preclinical |
| CHEMBL5070553 | 9.49 | Kd | 0.326 | Preclinical |
| CHEMBL5426285 | 9.41 | Kd | 0.388 | Preclinical |
| CHEMBL5081787 | 9.4 | Kd | 0.395 | Preclinical |
| CHEMBL1230165 | 9.27 | Kd | 0.54 | Clinical |
| CHEMBL5279705 | 9.24 | Kd | 0.58 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 367 | 456 | 7.0 |
| assay format | 81 | 136 | 6.5 |
| cell-based format | 59 | 320 | 7.1 |
| biochemical format | 1 | 0 | — |
| subcellular format | 1 | 36 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 1 | 5.9 |
| assay format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.6 |