GABA transporter 2 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P31651. Use UniProt P31651 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31651 as the stable identity anchor, then attach disease evidence before program review.
Sodium- and chloride-dependent betaine transporter
Review this target as GABA transporter 2, mapped to UniProt P31651. ChEMBL maps the protein component as Sodium- and chloride-dependent betaine transporter. Sequence length is 614 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats GABA transporter 2 as ChEMBL target CHEMBL4228, mapped to UniProt P31651. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GABA transporter 2 is the right protein anchor across sources, using UniProt P31651 as the stable mapping.
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| Preferred Name | GABA transporter 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P31651 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sodium- and chloride-dependent betaine transporter |
| UniProt Accession | P31651 |
| Component Type | Protein |
| Sequence Length | 614 aa |
Sodium- and chloride-dependent betaine transporter
Review this target as GABA transporter 2, mapped to UniProt P31651. ChEMBL maps the protein component as Sodium- and chloride-dependent betaine transporter. Sequence length is 614 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1027 | 6.75 | IC50 | 180.0 | Approved |
| CHEMBL1446457 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL1446457 | 5.85 | Ki | 1400.0 | Preclinical |
| CHEMBL1773934 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL5411369 | 5.52 | IC50 | 3000.0 | Preclinical |
| CHEMBL77575 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL4781266 | 5.35 | IC50 | 4466.84 | Preclinical |
| CHEMBL4854996 | 5.34 | IC50 | 4570.88 | Preclinical |
| CHEMBL4858459 | 5.24 | IC50 | 5754.4 | Preclinical |
| CHEMBL3289583 | 5.23 | IC50 | 5888.44 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 32 | 216 | 4.7 |
| single protein format | 3 | 8 | 5.3 |