Squalene monooxygenase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P52020. Use UniProt P52020 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P52020 as the stable identity anchor, then attach disease evidence before program review.
Squalene monooxygenase
Review this target as Squalene monooxygenase, mapped to UniProt P52020. Sequence length is 573 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Squalene monooxygenase as ChEMBL target CHEMBL4241, mapped to UniProt P52020. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Squalene monooxygenase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P52020 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Squalene monooxygenase |
| UniProt Accession | P52020 |
| Component Type | Protein |
| Sequence Length | 573 aa |
Squalene monooxygenase
Review this target as Squalene monooxygenase, mapped to UniProt P52020. Sequence length is 573 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL434998 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL336565 | 9.18 | IC50 | 0.66 | Preclinical |
| CHEMBL134888 | 9.06 | IC50 | 0.87 | Preclinical |
| CHEMBL337391 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL133373 | 8.35 | IC50 | 4.5 | Preclinical |
| CHEMBL16121 | 7.21 | IC50 | 61.0 | Preclinical |
| CHEMBL86248 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL349197 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL382408 | 6.33 | IC50 | 470.0 | Preclinical |
| CHEMBL39504 | 6.27 | IC50 | 540.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 40 | 5.7 |
| single protein format | 3 | 15 | 5.7 |
| organism-based format | 2 | 0 | — |
| cell-based format | 1 | 1 | 5.2 |
| tissue-based format | 1 | 4 | 5.2 |