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Target Snapshot

CHEMBL4258 Target Snapshot

Subtilisin BL · SINGLE PROTEIN · Bacillus lentus

12Compounds
3Assays
0Approved Drugs
36.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P29599. Use UniProt P29599 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P29599 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Subtilisin BL as ChEMBL target CHEMBL4258, mapped to UniProt P29599. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Subtilisin BL
SINGLE PROTEIN · Bacillus lentus
As of 2026-09-14
ChEMBL target ID
CHEMBL4258
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P29599
Subtilisin BL
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Subtilisin BL is the right protein anchor across sources, using UniProt P29599 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSubtilisin BL
UniProt AccessionP29599
Component TypeProtein
Sequence Length269 aa

Subtilisin BL

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Subtilisin BL, mapped to UniProt P29599. Sequence length is 269 aa.

Mapped IDP29599
Review nameSubtilisin BL
OrganismBacillus lentus
Assay Mix

Activity Type Distribution

KI36.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL20726 5.1 Ki 8000.0 Preclinical
CHEMBL20866 5.0 Ki 10000.0 Preclinical
CHEMBL20945 4.82 Ki 15000.0 Preclinical
CHEMBL20421 4.51 Ki 31000.0 Preclinical
CHEMBL20852 4.14 Ki 73000.0 Preclinical
CHEMBL20461 4.02 Ki 95000.0 Preclinical
CHEMBL21485 4.02 Ki 96000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
12
Tested Compounds
1
Assay Types
Binding — 3 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 12 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine