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Target Snapshot

CHEMBL4263 Target Snapshot

Acetolactate synthase, chloroplastic · SINGLE PROTEIN · Arabidopsis thaliana

186Compounds
14Assays
0Approved Drugs
111.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P17597. Use UniProt P17597 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P17597 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Acetolactate synthase, chloroplastic as ChEMBL target CHEMBL4263, mapped to UniProt P17597. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Acetolactate synthase, chloroplastic
SINGLE PROTEIN · Arabidopsis thaliana
As of 2026-09-14
ChEMBL target ID
CHEMBL4263
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P17597
Acetolactate synthase, chloroplastic
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Acetolactate synthase, chloroplastic is the right protein anchor across sources, using UniProt P17597 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAcetolactate synthase, chloroplastic
UniProt AccessionP17597
Component TypeProtein
Sequence Length670 aa

Acetolactate synthase, chloroplastic

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Acetolactate synthase, chloroplastic, mapped to UniProt P17597. Sequence length is 670 aa.

Mapped IDP17597
Review nameAcetolactate synthase, chloroplastic
OrganismArabidopsis thaliana
Assay Mix

Activity Type Distribution

IC5049.0
KI62.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1231791 8.1 Ki 8.0 Preclinical
CHEMBL2289307 8.01 IC50 9.772 Preclinical
CHEMBL2289344 7.82 IC50 15.14 Preclinical
CHEMBL2289326 7.68 IC50 20.89 Preclinical
CHEMBL2289316 7.67 IC50 21.38 Preclinical
CHEMBL2289345 7.66 IC50 21.88 Preclinical
CHEMBL2289301 7.65 IC50 22.39 Preclinical
CHEMBL2289343 7.62 IC50 23.99 Preclinical
CHEMBL2289319 7.53 IC50 29.51 Preclinical
CHEMBL2251593 7.49 IC50 32.36 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
6
5.5
3
6.0
11
6.5
8
7.0
8
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
86
Tested Compounds
1
Assay Types
Binding — 14 assays, 86 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 83 6.0
assay format 1 3 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine