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Target Snapshot

CHEMBL4267 Target Snapshot

TGF-beta receptor type-2 · SINGLE PROTEIN · Homo sapiens

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1,492Compounds
185Assays
8Approved Drugs
1,354.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P37173. Use UniProt P37173 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P37173 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats TGF-beta receptor type-2 as ChEMBL target CHEMBL4267, mapped to UniProt P37173. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
TGF-beta receptor type-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4267
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P37173
TGF-beta receptor type-2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether TGF-beta receptor type-2 is the right protein anchor across sources, using UniProt P37173 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTGF-beta receptor type-2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP37173
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTGF-beta receptor type-2
UniProt AccessionP37173
Component TypeProtein
Sequence Length567 aa

TGF-beta receptor type-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as TGF-beta receptor type-2, mapped to UniProt P37173. Sequence length is 567 aa.

Mapped IDP37173
Review nameTGF-beta receptor type-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
3
Phase III
7
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50997.0
KI1.0
KD356.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4791414 9.51 IC50 0.31 Preclinical
CHEMBL4758580 9.25 IC50 0.56 Preclinical
CHEMBL4787891 9.21 IC50 0.61 Preclinical
CHEMBL4751832 9.08 IC50 0.83 Preclinical
CHEMBL4748097 9.0 IC50 1.0 Preclinical
CHEMBL4752199 9.0 IC50 1.0 Preclinical
CHEMBL4779273 8.96 IC50 1.1 Preclinical
CHEMBL4782729 8.92 IC50 1.2 Preclinical
CHEMBL2385579 8.86 IC50 1.37 Preclinical
CHEMBL4741185 8.82 IC50 1.5 Preclinical
Distribution

pChEMBL Value Distribution

144
5.0
108
5.5
90
6.0
46
6.5
18
7.0
8
7.5
9
8.0
8
8.5
5
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

185
Total Assays
439
Tested Compounds
1
Assay Types
Binding — 185 assays, 439 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 144 379 6.0
assay format 23 1 6.2
cell-based format 12 43 5.9
subcellular format 6 16 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine