Use UniProt Q27963 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4271 Target Snapshot
Synaptic vesicular amine transporter · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt Q27963. Use UniProt Q27963 as the stable identity anchor, then attach disease evidence before program review.
Synaptic vesicular amine transporter
Review this target as Synaptic vesicular amine transporter, mapped to UniProt Q27963. Sequence length is 517 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Synaptic vesicular amine transporter as ChEMBL target CHEMBL4271, mapped to UniProt Q27963. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Synaptic vesicular amine transporter |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | Q27963 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Synaptic vesicular amine transporter |
| UniProt Accession | Q27963 |
| Component Type | Protein |
| Sequence Length | 517 aa |
Synaptic vesicular amine transporter
How to read this target
Review this target as Synaptic vesicular amine transporter, mapped to UniProt Q27963. Sequence length is 517 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL772 | 9.0 | Ki | 1.0 | Approved |
| CHEMBL117785 | 8.4 | Ki | 4.0 | Approved |
| CHEMBL272202 | 6.4 | Ki | 400.0 | Preclinical |
| CHEMBL404601 | 6.3 | Ki | 500.0 | Preclinical |
| CHEMBL406761 | 5.85 | Ki | 1400.0 | Preclinical |
| CHEMBL271568 | 5.62 | Ki | 2400.0 | Preclinical |
| CHEMBL272201 | 5.55 | Ki | 2800.0 | Preclinical |
| CHEMBL270469 | 5.35 | Ki | 4500.0 | Preclinical |
| CHEMBL270771 | 5.12 | Ki | 7600.0 | Preclinical |
| CHEMBL411716 | 5.0 | Ki | 10000.0 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 6 assays, 50 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 50 | 4.9 |