cGMP-dependent protein kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Protein identity stays anchored to UniProt Q13976. Use UniProt Q13976 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13976 as the stable identity anchor, then attach disease evidence before program review.
cGMP-dependent protein kinase 1
Review this target as cGMP-dependent protein kinase 1, mapped to UniProt Q13976. Sequence length is 671 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cGMP-dependent protein kinase 1 as ChEMBL target CHEMBL4273, mapped to UniProt Q13976. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cGMP-dependent protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13976 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cGMP-dependent protein kinase 1 |
| UniProt Accession | Q13976 |
| Component Type | Protein |
| Sequence Length | 671 aa |
cGMP-dependent protein kinase 1
Review this target as cGMP-dependent protein kinase 1, mapped to UniProt Q13976. Sequence length is 671 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1990254 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL5278787 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4448806 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL388978 | 8.95 | IC50 | 1.12 | Preclinical |
| CHEMBL3752910 | 8.9 | Kd | 1.245 | Preclinical |
| CHEMBL1998121 | 8.9 | Ki | 1.259 | Preclinical |
| CHEMBL2001751 | 8.9 | Ki | 1.259 | Preclinical |
| CHEMBL2023841 | 8.89 | Kd | 1.3 | Preclinical |
| CHEMBL60254 | 8.8 | Kd | 1.6 | Preclinical |
| CHEMBL1976240 | 8.6 | Ki | 2.512 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 279 | 83 | 6.0 |
| assay format | 50 | 0 | — |
| cell-based format | 22 | 36 | 5.3 |
| subcellular format | 1 | 5 | 6.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 130 | 6.7 |