Use UniProt Q5BJR8 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4277 Target Snapshot
Retinoic acid receptor RXR-gamma · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q5BJR8. Use UniProt Q5BJR8 as the stable identity anchor, then attach disease evidence before program review.
Retinoic acid receptor RXR-gamma
Review this target as Retinoic acid receptor RXR-gamma, mapped to UniProt Q5BJR8. Sequence length is 463 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Retinoic acid receptor RXR-gamma as ChEMBL target CHEMBL4277, mapped to UniProt Q5BJR8. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Retinoic acid receptor RXR-gamma |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q5BJR8 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Retinoic acid receptor RXR-gamma |
| UniProt Accession | Q5BJR8 |
| Component Type | Protein |
| Sequence Length | 463 aa |
Retinoic acid receptor RXR-gamma
How to read this target
Review this target as Retinoic acid receptor RXR-gamma, mapped to UniProt Q5BJR8. Sequence length is 463 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL340074 | 8.72 | Ki | 1.9 | Preclinical |
| CHEMBL340555 | 8.6 | Ki | 2.5 | Preclinical |
| CHEMBL133176 | 8.31 | Ki | 4.9 | Preclinical |
| CHEMBL339298 | 8.31 | Ki | 4.9 | Preclinical |
| CHEMBL335751 | 8.18 | Ki | 6.6 | Preclinical |
| CHEMBL129887 | 8.16 | Ki | 6.9 | Preclinical |
| CHEMBL336086 | 8.12 | Ki | 7.6 | Preclinical |
| CHEMBL131561 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL42314 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL335762 | 7.86 | Ki | 13.9 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 17 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 17 | 7.9 |