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Target Snapshot

CHEMBL4282 Target Snapshot

RAC-alpha serine/threonine-protein kinase · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
7,395Compounds
1,631Assays
5Approved Drugs
8,097.0Activities
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Broader Open DB context

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As of 2026-09-13

RAC-alpha serine/threonine-protein kinase shows clinical signal disease relevance led by neoplasm. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P31749. Start with neoplasm, then reuse UniProt P31749 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with neoplasm, then reuse UniProt P31749 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
neoplasm

RAC-alpha serine/threonine-protein kinase shows clinical signal disease relevance led by neoplasm. 2 linked drugs remain visible in the same block.

Start review with neoplasm because it currently carries clinical signal support. Linked drugs include BAY-1125976, RUPITASERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RAC-alpha serine/threonine-protein kinase as ChEMBL target CHEMBL4282, mapped to UniProt P31749. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RAC-alpha serine/threonine-protein kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4282
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P31749
RAC-alpha serine/threonine-protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RAC-alpha serine/threonine-protein kinase is the right protein anchor across sources, using UniProt P31749 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
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Overview

Basic Information

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Preferred NameRAC-alpha serine/threonine-protein kinase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP31749
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRAC-alpha serine/threonine-protein kinase
UniProt AccessionP31749
Component TypeProtein
Sequence Length480 aa

RAC-alpha serine/threonine-protein kinase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as RAC-alpha serine/threonine-protein kinase, mapped to UniProt P31749. Sequence length is 480 aa.

Mapped IDP31749
Review nameRAC-alpha serine/threonine-protein kinase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

RAC-alpha serine/threonine-protein kinase shows clinical signal disease relevance led by neoplasm.

Clinical signal Phase II
neoplasm
2 linked drugs · 2 direct · 2 efficacy
Linked drugBAY-1125976
Linked drugRUPITASERTIB
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with neoplasm because it currently carries clinical signal support. Linked drugs include BAY-1125976, RUPITASERTIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseneoplasm
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

5
Approved
10
Phase III
14
Phase II
10
Phase I
Assay Mix

Activity Type Distribution

IC506,570.0
KI884.0
EC5025.0
KD618.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5407182 10.7 IC50 0.02 Preclinical
CHEMBL5406146 10.64 IC50 0.023 Preclinical
CHEMBL523586 10.52 Ki 0.03 Preclinical
CHEMBL5414576 10.46 IC50 0.035 Preclinical
CHEMBL5398425 10.44 IC50 0.036 Preclinical
CHEMBL469590 10.4 Ki 0.04 Preclinical
CHEMBL520788 10.3 Ki 0.05 Preclinical
CHEMBL5437264 10.28 IC50 0.053 Preclinical
CHEMBL5428430 10.27 IC50 0.054 Preclinical
CHEMBL470597 10.22 Ki 0.06 Preclinical
Distribution

pChEMBL Value Distribution

473
5.0
551
5.5
753
6.0
923
6.5
861
7.0
789
7.5
900
8.0
536
8.5
159
9.0
49
9.5
pChEMBL
Approved Drugs

Approved Drugs

CAPIVASERTIB
CHEMBL2325741
Approved 2023
Properties Compare Identifier
MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,631
Total Assays
4,085
Tested Compounds
4
Assay Types
Binding — 1,601 assays, 4,085 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 930 2,599 7.1
cell-based format 555 1,041 7.0
assay format 106 440 7.2
subcellular format 10 5 6.6
Functional — 22 assays, 184 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 17 6.8
assay format 8 167 5.8
ADME — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0 —
single protein format 2 0 —
assay format 1 0 —
Toxicity — 1 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 16 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine