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Target Snapshot

CHEMBL4295533 Target Snapshot

Prolyl oligopeptidase family protein · SINGLE PROTEIN · Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

2Compounds
1Assays
0Approved Drugs
2.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt A6H249. Use UniProt A6H249 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A6H249 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prolyl oligopeptidase family protein as ChEMBL target CHEMBL4295533, mapped to UniProt A6H249. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prolyl oligopeptidase family protein
SINGLE PROTEIN · Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
As of 2026-09-14
ChEMBL target ID
CHEMBL4295533
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
A6H249
Prolyl oligopeptidase family protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Prolyl oligopeptidase family protein is the right protein anchor across sources, using UniProt A6H249 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProlyl oligopeptidase family protein
UniProt AccessionA6H249
Component TypeProtein
Sequence Length633 aa

Prolyl oligopeptidase family protein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Prolyl oligopeptidase family protein, mapped to UniProt A6H249. Sequence length is 633 aa.

Mapped IDA6H249
Review nameProlyl oligopeptidase family protein
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Assay Mix

Activity Type Distribution

IC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4214751 6.11 IC50 770.0 Preclinical
CHEMBL458248 5.92 IC50 1200.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 2 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine